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Abstract

Coronary artery disease (CAD is one of the major causes of morbidity and mortality in the world. Increased plasma (p) fibrinogen levels are closely related to myocardial ischemia and acute coronary events. This study aimed to evaluate changes in fibrinogen and other biochemical parameters in CAD patients with and without diabetes mellitus (DM). The total of 120 individuals aged 23–86 years were separated into three groups: 40 patients with CAD and DM (G1), 40 patients with CAD without DM (G2), and 40 apparently healthy subjects serving as controls (G3). Levels of plasma fibrinogen were analyzed in all samples using a sandwich enzyme-linked immunosorbent assay (ELISA). Additionally, serum glucose, lipid profile, Troponin I, and CK-MB levels were measured in the studied groups. This study demonstrated significant elevations in P. fibrinogen levels in G1 and G2 compared to healthy controls, with the highest values observed in GI patients (P < 0.01). Analysis of routine biomarkers revealed significant differences across groups, except for triglycerides, which remained unchanged (P = 0.069). Correlation analysis showed that in the GI group, fibrinogen levels were positively associated with troponin I. In contrast, in the GII group, fibrinogen was positively associated only with LDL and significantly with cholesterol. This study concluded that the abnormal clotting process occurs in CAD patients.

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