Abstract
Chronic wounds pose major clinical and economic challenges, especially in patients with comorbidities or impaired healing responses. This study presents NanoSeal-X™, a bioinspired multifunctional wound dressing engineered to address distinct biological demands at each phase of healing. The theoretical construct integrates a dual-layer matrix: a hyaluronic acid-based hydrogel embedded with silver nanoparticles, amoxicillin, and lidocaine, supported by a chitosan-based scaffold. Each component is strategically selected to provide hemostasis, infection control, tissue regeneration, and pain relief. This work presents a theoretical design framework to guide the development of multifunctional wound dressings. NanoSeal-X™ integrates pharmacological and bioactive components aligned with distinct healing phases, and serves as a translational scaffold for future empirical and clinical validation.
First Page
35
Last Page
39
Recommended Citation
Ghadban, Mohammed Mahdi Salman
(2025)
"NanoSeal-X: A Theoretical Design for a Phase-Aligned Multifunctional Wound Dressing Based on Chitosan–HA–Nanoparticle Composite,"
Al-Nisour Journal for Medical Sciences: Vol. 7:
Iss.
2, Article 5.
DOI: https://doi.org/10.70492/2664-0554.1148