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Abstract

Background: Hepatitis C viral(HCV) infection is a medical condition marked by liver inflammation that represents a significant global public health problem and often causes fibrosis/cirrhosis and hepatocellular carcinoma.

Objective: This study aims to evaluate the changes in some biochemical parameters in chronic viral hepatitis c patients in Iraq. Among the biochemical parameters used to measure liver function were total Bilirubin (TBL), direct Bilirubin (DBL), indirect Bilirubin (IBL), alkaline phosphatase (ALP), Glutamic Oxaloacetic Transaminase (GOT), and glutamic-pyruvic transaminase(GPT). The lipid profile also included low-density lipoprotein, TG, and cholesterol.

Methods: 150 blood specimens were collected, 100 individuals were infected with viral hepatitis C, and 50 were used as healthy controls at the Baghdad Gastroenterology and Hepatology Teaching Hospital Ministry of Health. The data collection took place between December 2023 and April 2024.

GOT, GPT, ALP, total bilirubin, indirect and direct bilirubin, cholesterol, triglyceride, and low-density lipoprotein were evaluated by mindray BA-88A.

Results: The study showed a slightly higher male patient frequency (52%)than females(48%) with no statistically significant difference (p= 0.86 ), indicating that the disease may influence both males and females but with a tendency to males. The patient exhibited a significant elevation p-value of less than 0.001 in serum levels of GOT, GPT, ALP, Total bilirubin, direct bilirubin, -indirect bilirubin, and Total cholesterol (46.75±12.81, 58.17±12.06, 599.11±149.64, 1.46±0.25, 0.6±0.14, 0.86±0.16, 151.39±36.155) respectively versus the control group. However, the two groups had no statistical variation in serum triglyceride and LDL levels (p>0.05).

Conclusions: The current study shows that individuals with HCV infection have higher levels of serum GOT (AST), GPT (ALT), ALP, Total bilirubin, direct Bilirubin, indirect Bilirubin, and Total cholesterol (TC) compared to the healthy control.

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