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Abstract

lupus arthritis it is a synovitis that affects two or more joints and is characterized by swelling, effusion, or pain in two or more joints that lasts at least 30 minutes in the morning. The main objectives of present study can be summarized. To study the serum levels of β-CTX in patients with lupus arthritis. Measure the effect of disease severity on the serum levels of β-CTX. To assess the specificity and sensitivity, cut off value of the factors. To evaluate the correlation of β-CTX with Age, ESR and S. Ca+ . This case-healthy individuals study was conducted on 131 lupus arthritis women and 50 healthy individuals over a period of 4 months, from November 2022 until March 2023. All lupus arthritis women who were included in the study were subjected to physical examination, age, and laboratory investigations, including urine examination, ESR and S. Ca+ . Clinical examinations were conducted depending on the specialty of the consultant doctor, and they were categorized according to the Roma Helper program into three groups (inactive, mild, and severe) according to the disease severity. The levels of β-CTX were significantly increased in lupus arthritis. The β-CTX levels were positive correlation with disease activity. β-CTX showed excellent diagnostic performances for lupus arthritis where results are shown AUC (0.99), Sensitivity (0.99), Specificity (0.70), Cut‐off points (905.78) and (P < 0.001) β-CTX was good indicator for severity of lupus arthritis. The result of β-CTX were positive correlation with ESR and Ca+ . In Conclusion the β-CTX levels were significantly increased in females with lupus arthritis. The β-CTX was good indicator for severity of lupus arthritis

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