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Abstract

Increased oxidative stress is a well-established negative factor leading to insulin resistance, β-cell dysfunction, dyslipidemia, and finally leading to type 2 diabetes mellitus and its complications The study aimed to investigate some oxidative biomarkers, lipid profiles, and their association with hyperglycemia in patients with type 2 diabetes and pre-diabetics and compared the result with healthy control group. The present study conducted a case control study on 180 participants (87 females and 93 males) between the ages of 30 and 70 years, from the first of July 2023 until the end of September 2023. The participants were divided into three groups that included 60 patients with type 2 diabetes, 60 patients with pre-diabetes, and 60 healthy cases as a control group. The objective of this research was to measure the levels of, serum fasting blood sugar, glycated hemoglobin, oxidative biomarkers, insulin, HOMAIR, serum lipid profiles were evaluated, and estimate the impact of age and BMI on the results. The results showed that the level of lipid peroxidase (LPO), fasting blood sugar, glycated hemoglobin, insulin, HOMAIR and lipid profile in patients with type 2 diabetes and pre-diabetics groups are significantly increase than those in the control groups, while SOD (superoxide dismutase), GPX (glutathione peroxidase) and HDL, significantly lower in diabetic and pre-diabetics than those in the control groups. In conclusion, T2DM and pre-diabetics are conditions with increased oxidative stress, and the condition necessitates the consumption of antioxidants to combat oxidants, resulting in decreased total antioxidant status and increased lipid peroxidase.

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142

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