•  
  •  
 

Abstract

COVID-19 patients showed changes in biochemical and hematological parameters which may cause other complications. D-dimer is one of the prognostic biomarkers used to predict COVID-19 infection, the elevated level of it considered one of the risk factors for mortality especially in adult COVID-19 patients and indicated the positive correlation between D-dimer and disease severity. Another biochemical biomarker is ferritin and CRP, which consider a key mediators of the immune dysregulation via direct immune suppressive and contributing to cytokine storm. This suggested the ferritin and CRP level might be considered a crucial factor influencing the severity of COVID-19. SARS-COV-2 also has affected the regulation of the immune response through an impaired immune system which includes lymphopenia, monocyte, and granulocyte abnormalities, as well as causes inflammatory immune response through elevated levels of cytokines, especially in COVID-19 critical cases. The aim of this study is the identification of COVID-19 patients by using hematological and biochemical Parameters. This study included 180 individuals of a variety of ages and both sexes, the subjects included 60 individuals who participated as healthy control RT-PCR COVID-19 negative, and 120 participants were introduced as COVID-19 patients were diagnosed by RT-PCR test from nasopharyngeal swabs. Based on the disease severity the patients were grouped into two groups each of which consisted of 60 patients, which included the mild-moderate group and the severe group. All participated were subjected to laboratory tests which included hematological and biochemical tests. Result of this study reveal that median of CRP, Ferritin, and D-dimer level in severe group higher than in other group’s mild-moderate and control. While median of monocyte count in mild-moderate group higher than in both control and severe group. Median of Lymphocyte count in control group higher than in both patients groups severe and mild-moderate. On other side the neutrophil median in severe group was higher than in another group’s mild-moderate and control. The result among NLR was reveal the median in severe group higher than mild-moderate and control with highly significant different. The data present in this current study reveal the alterations among biochemical and hematological parameters in COVID-19 patients correlated significantly with disease severity and propagation and can used as prognostic predictive markers for disease severity.

First Page

118

Last Page

128

Download

Share

COinS