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Abstract

Acute coronary syndrome (ACS) is the umbrella of ischemic myocardial diseases and involves unstable angina (UA), non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI). UA and NSTEMI, share similar pathophysiology, but at increasing severity. The study aimed to assess the levels of stem cell factor (SCF)in acute coronary syndrome patients infected with Covid-19 in Baghdad Governorate, and healthy subjects and to analyze the levels of lipid profile including total cholesterol (TC), triglyceride (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL) as well as very low density lipoproteins (VLDL). one hundred patients with acute coronary syndrome were divided into two groups 50 ACS with COVID-19 infected patients and 50 ACS without COVID-19 infected, and 50 healthy controls. Levels of serum stem cell factor (SCF) were analyzed by ELISA technique and serum levels of lipid profile were measured manually by Spectrophotometer. The (ACS COVID-19 infected and ACS without COVID19 infected) patients had lower levels of stem cell factor (SCF) as compared to healthy controls (P≤0.01). TC, LDL, TG, and VLDL concentrations in the sera were higher in (ACS without COVID19 & ACS with COVID-19) patients, while lower levels of HDL in the same patients when compared with healthy control. The present study exhibited lower serum SCF levels in both groups ACS with COVID-19 infected and ACS without COVID-19 infected patients compared to healthy controls. Therefore, SCF can be considered a biomarker for ACS with COVID-19 infected and ACS without COVID-19 infected

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