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Adel Amen Hama

Abstract

The drug-induced state of general anesthesia prevents patients from being awakened even by painful overstimulation. Depressed spontaneously respiration or drug-induced decrease of muscle control may necessitate the ability to autonomously maintain a patent airway and positive pressure breathing. Aim of study: To compare the induction dose of propofol, while using either ketamine or midazolam as co induction agent. This prospective study was conducted in “Baghdad Teaching Hospital” from 3rd (October) 2020-20th (April) 2021. Forty patients were enrolled in this study. The patients were randomly collected and divided in two groups according to drug combination they received, group A and group B comprising 20 patients for each. The patients of group A were given ketamine (0.5mg/kg) and group B patient's midazolam (0.03 mg/kg) of midazolam were preparedas co-induction agent for propofol. Induction of anesthesia performed with sleeping dose of propofol which were recorded for each patient. After induction of anesthesia intubation done with the aid of non-depolarizing muscle relaxant Intermediate-acting (Atracurium or Rocuronium with different dose). All continuous variables i.e. patient’s hemodynamic responses (Pulse rate, systolic and diastolic blood pressure), time of sleepiness and dose of propofol was presented by mean ± standard deviation (SD). P value off <0.05 was considered statistically significant. In this study we found a minimally dissmilarities in induction dosage of propofol between G.A and G.B was (0.1 mg) with a (p-value 0.5). We encompass patients of male and female and property to ASA-I and ASA-II physical status. They found mean induction dosage of propofol of (1.2 mg/kg) with ketamine propofol group and (1.4 mg/kg) with midazolam propofol group. Only The difference between the two groups only 7%. The difference in this study in the mean induction dosage of propofol not statistically significant (P-value 0.5). Depended on results of study, we can conclude that is not dissmilarities in the mean induction dosage of ketamine-propofol and midazolam-propofol co-induction.

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186

Last Page

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