Abstract
Cancer disorders are the world's second leading cause of death caused in 90% of cases but the development of metastasis, that are the clinical result of the extremely invasive behavior of cancer, metastasis is the major cause of cancer-related deaths. The Metastatic suppressor activity of Kisspeptin system was identified cancer cells The current study aimed to reveal the relationship between kisspeptin and CA15-3, Ca125 in women with breast and ovarian cancers. The study included 142 women, 61 confirmed breast cancer 41 ovarian cancer, and 40 apparently healthy control whose ages ranging between 40-57 years. CA15-3, CA125, and kisspeptin-54 were determined in serum of all subjects. Depending on breast cancer, BMI level raised significantly in cancer women with non-metastasis compared with metastasis and healthy women, BMI level raised significantly in ovarian cancer women with non-metastasis when compared with metastasis], and healthy women. Kisspeptin level increased significantly in women with non-metastasis breast cancer but it decreases significantly in women with metastasis when compared with healthy women. Kisspeptin level showed increased significantly in women with non-metastasis and metastasis when compared with healthy women. We found a negative correlation between kisspeptin and CA125 in ovarian cancer patients with metastasis. The body mass of women with breast and ovarian cancer increases with non-metastatsis Kisspeptin 54 and CA125 immunoreactivity are substantially linked to ovarian cancer, making them the first independent predictive biomarkers for the disease.
First Page
1
Last Page
13
Recommended Citation
Elia, Zaid Nabeel; Mustafa, Nisreen Waleed; and Ibrahim AL-Mahdawi, Fatimah Kadhim
(2023)
"Kisspeptin 54 as biomarker for breast and ovarian cancer,"
Al-Nisour Journal for Medical Sciences: Vol. 5:
Iss.
1, Article 1.
DOI: https://doi.org/10.70492/2664-0554.1089