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Abstract

Coronavirus disease 2019 (COVID-19) SARS-2 is a respiratory tract infection with a newly recognized coronavirus thought to have originated as a zoonotic virus that has mutated or otherwise adapted in ways that allow human pathogenicity. This study describe the association between IL-6, D-dimer, C-reactive protein (CRP, Ferritin, erythrocyte sedimentation rate (ESR), and hematological marker in a cohort of COVID-19 patients. The baseline characteristics of the studied samples according to age and gender with a comparison of significance in studied groups show that a total of 65 individuals were divided into three groups according to the severity of disease (17 milds, 24 moderates, and 24 severe). Moreover, no significant difference was reported in the current study according to age groups between male and female groups at P>0.05. The laboratory tests included hematological, biochemical detections, and inflammatory biomarkers. A significant increase in neutrophil counts, but decrease in lymphocyte count. While normal reading in platelet count, HB, and PCV. There were a significantly higher D-dimer and serum ferritin in the severe patient, farther increased in inflammatory marker C-reactive protein, erythrocyte sedimentation rate in moderate and sever patients (p < 0.05). Moreover, analysis of serum levels of Il-6 showed a highly significant difference in the mean value in patients groups. In Conclusion, serum IL-6 is important marker of inflammation identifying this elevated lies in the potential use of antibody against IL‐6 that can guide the clinicians in recognizing patients with severe COVID‐19 early in the disease. The potential risk factors of old age, high baseline of D-dimer, dynamic of ferritin, CRP, and ESR could help clinicians to identify and treat subjects with poor prognosis.

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