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Abstract

Chronic kidney disease (CKD) is a major social health problem. CKD is ranked –5 rd amongst life threatening disease in Iraq, the death rate in 2015 of about 6879 patients because of renal failure according to the statistics of the Republic of Iraqi-Ministry of Health/Environment. We aimed to evaluated (IL-6 & TNF-α) in Iraqi patients with chronic renal failure and assess some biochemical parameters include (urea, creatinine, sodium, potassium and calcium).This study included 60 cases and classified as 30 patients with chronic renal failure, these patients with age range (15years and above) who were admitted to the Al-kadimyiah Teaching Hospital, Baghdad Teaching Hospital during the period from December 2020 to March 2021and compared with 30 apparent healthy controls with age range (15-65). Laboratory was depended on using spectrophotometry for detection biochemical tests. IL-6 & TNFα levels were estimation by Enzyme Linked Immuno-sorbent assay (ELISA). It was observed that majority of patients with chronic renal failure within age group (40- 60) years that account (60%), most of these patients were females that constituted (73.3%). Furthermore, preponderance diseases associated with chronic renal patients were associated with Diabetes Mellitus (23.33%). Regarding biochemical parameters, it was observed that serum urea (S.urea), serum creatinine (S.creatinine) ,serum potassium (S. K) were increased in chronic renal cases and decrease in Serum calcium (S. Ca,),Serum sodium (S. Na ) in comparison with healthy control group. Considering some cytokines (IL-6, TNFα) revealed increase levels of IL-6 &TNFα significantly (26.26 ±1.48),( 92.96 ±1.80) respectively in chronic renal patients when compared with control group(13.02 ±0.34),( 66.55 ±0.45) respectively. Highly significant elevated of pro-inflammatory cytokines which include IL6&TNFα in chronic renal diseases indicated these cytokines participate in the pathophysiology of reduced renal function and role of these cytokines as principle mediators of inflammatory reaction in renal damage and these cytokines could be potential therapeutic targets.

First Page

156

Last Page

168

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