Abstract
Telomerase-associated protein 1 is responsible ribonucleoprotein complex for telomerase activity, which catalyzes new telomeres on the chromosome ends. The presented work studied the impact of (TEP1) single nucleotide polymorphism on bladder CA risk. A total of sixty-two diagnosed by histopathologically with Transitional cell carcinoma (TCC) individuals and thirty-eight individuals as controls were implicated in the research. TEP1 rs222804 Polymorphism (C>T) was estimated by amplifying the gene with PCR and DNA sequencing methods. This study revealed that the polymorphic T allele related to TEP1 rs222804 Polymorphism has a considerable association in increase TCC risk with an odds ratio of 4.7. Also, a significant association has been observed between T allele and increasing TCC risk among smoker individuals 7.02 (1.48-33.25), p=0.01. Furthermore, the T allele showed a significant association for the T2 stage of TCC (OR=13.2, 95 % CI=2.7-64.1), p=0.001. This data leads to suggestions that the TEP1 rs222804 genotype could be involved in increasing TCC risk.
First Page
117
Last Page
130
Recommended Citation
Al-Qadoori, Saleh Ali and Dawood, Farah A.
(2022)
"Polymorphism with Bladder Cancer Risk and Staging,"
Al-Nisour Journal for Medical Sciences: Vol. 4:
Iss.
2, Article 12.
DOI: https://doi.org/10.70492/2664-0554.1082