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Abstract

The present study was carried out to evaluate liver function and estimate specific cardiac biomarker in 200 subject including 150 recovered Covid-19 Patients and 50 healthy control groups. GOT, GPT, ALP and LDH isoenzyme were estimated using CUSIBIO protocol. While LDH isoenzymes were also estimated using CUSBIO protocol. The data revealed increase levels of liver enzyme GOT, GPT and ALP in recovered patients, while the LDH isoenzyme showed increasing level of LDH2, LDH3, and LDH4 except LDH1 revealed decrease level. We conclude that the dysregulation in liver function and increase of liver enzyme is due to the present the ACE2 as Covid-19 receptors in cholangiocyte of liver. Some LDH iso enzymes are existing in several human organ including lung, kidney and intestine when the Covid19 attack these members lead to pathophysiological changes in level of some LDH isoenzymes. The study included 200 subjects, 150 recovered patients and 50 healthy control and age from 15-65 years. Was conducted in Baghdad teaching hospital/ Baghdad- Iraq from July to September 2021, all patients had recovered from covid19.The following parameter were evaluated using different protocol (GPT, GOT, ALP) measured by the Automation method, while (LDH1, LDH2, LDH3, LDH4) were measured by the method obtained with CUSBIO. The results revealed an increased level of both GPT, GOT and ALP in recovered patients in comparison with healthy control. And also (LDH2, LDH3 and LDH4) showed increasing in recovered patients compared with healthy control; while showed decrease in LDH1 of both recovered patients compared healthy control. We conclude that the attack by Covid-19 leads to abnormal changes in biochemical parameters. It concludes that the dysregulation in liver function and increase of liver enzyme is due to the presence of ACE2 as Covid-19 receptors in cholangiocyte of liver. Also the pathophysiological changes in level of some LDL isoenzymes due to it are existing in several human organ including lung, kidney and intestine which are attacked by Covid-19.

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