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Abstract

Background: Trace elements are defined as dietary minerals which are present in minute quantities (˂0.01 %) of the organism mass. They are important for normal growth, development, maintenance and recovery of the human body health, it is classified as macro minerals up 60 to 80 percent material of the organism. Those elements are Ca, P, Mg, Na, K, Cl – and S. Those elements are necessary in amounts of more than 100 mg per day. Whereas the (microminerals) are needed in amounts of less than 100 mg per day. Zinc is one of the highly significant of trace elements in the body human is Zinc, its importance is noticed in developing central nervous system. Zinc deficiency furthers cancer by inhibiting normal vitamin A and DNA repair and lipid metabolism. Zinc is an plays important roles in cellular metabolism. Selenium(Se) was as an element of the glutathione peroxidase enzyme which, combined with vitamin E, superoxide dismutase and catalase, represents a component of one of the body, s anti-oxidant defense systems. This study aimed to identify the study of trace elements (Zinc and Selenium) among lraqi patients with liver cancer. Subject and Methods: This is a cross section study was conducted at three main medicals. facilities in Baghdad: The Main Training Center for Tumors/Oncology Teaching Hospital, Poisoning Consultation Center and Ministry of Science & Technology during the period from November/2019 to February/2020 to identify the estimation of the serum levels of zinc and selenium, the information regarding the study was obtained according to questioner (gender, age, liver disease, drug uses, and alcohol were recorded( . Results: Both groups were matching. All patients with primary liver cancer and metastasis. Serum levels of zinc (72.24±7.50 mg/dl vs 70.89±7.27, p ˂ 0.01) and selenium (52.65± 14.27 mg/dl vs 49.11±13.37, p ˂ 0.01) were significantly lower among patients with HCC compared to normal subject. Conclusions: Lower serum levels of zinc and selenium can be associated with a higher risk of liver cancer development.

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