In vitro Antibacterial Activity of Wedelolactone from Eclipta alba Against Human Pathogenic Bacteria

Authors

Zainab Abbas Shanshool

Abstract

Aerial parts of Eclipta alba are used traditionally for the treatment of several diseases of liver, skin and stomach. Methanolic extract and active principle compound of Iraq herb, Eclipta alba was tested for in vitro antimicrobial studies. It was evaluated using zone of inhibition studies and minimum inhibitory concentration was observed at the concentration of (0.08,0.04,0.02,0.01) g/ml against pathogenic bacteria. Phytochemical screening of the extract revealed the presence of active principles, coumestans (Wedelolactone), Alkaloids, Flavonoid, Glycosides, Triterpenoids, Tannins and Saponins. Methanolic extract fraction (wedelolactone) showed enhanced antimicrobial activity. Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Acinetobacter ssp. were most pathogen and resistant bacterial strain. These results suggest coumestans/wedelolactone as a promising antimicrobial agent.

First Page

25

Last Page

33

Recommended Citation

Shanshool, Zainab Abbas (2020) "In vitro Antibacterial Activity of Wedelolactone from Eclipta alba Against Human Pathogenic Bacteria," Al-Nisour Journal for Medical Sciences: Vol. 2: Iss. 1, Article 4.
DOI: https://doi.org/10.70492/2664-0554.1047