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Abstract

This study was carried out to investigate the role of both Vitamin C and calcium chloride in protection against the deterioration effect of sodium fluoride (NaF) exposure on kidney function .Fifty adult male rats were used, which divided randomly into five equal groups, the first group: The animals of this group served as control group administrated distilled water orally by gavage. Second group: administrated NaF (5.2mg/kg.bw/day) orally by gavage. Third group: administrated NaF (5.2mg/kg.bw/day) + Calcium Chloride (20mg/kg.bw/day) orally by gavage. Fourth group: administrated NaF (5.2mg/kg.bw/day) + Vitamin C (100mg/kg.bw/day) was given orally by gavage. Fifth group: administrated NaF (5.2mg/kg.bw/day) + Calcium Chloride (20mg/kg.bw/day) + Vitamin C (100mg/kg.bw/day) orally by gavage. The treatment continued for 45 days. At the end of the experiment, animals were sacrificed under anesthesia. Blood samples were taken and the serum was separated for the study of the urea, creatinine, and total protein and tissue samples of the kidney were taken for histological changes. The study showed a significant increase in the concentration of creatinine and urea in the fluoride treated group compared to the control group, while a significant improvements in these parameters were observed in all treated groups and in different degrees compared to the non-treated fluoride group. However, histological examination of the kidney in NaF treated group shows enlarged glomerulus, destruction of cuboidal epithelium of renal tubules. .

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