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Jasim M. Muhsin

Abstract

Autoimmune diseases are complex and happens when the human immune system attacks tissue host for unknown etiology or maybe by some other genetic cofactors or environmental agents (mainly viral particles, bacterial and other infectious agents; by acting as a major cofactors and serving as important initiators in the disease progression for a specific autoimmune sickness and not causing illness on their own) or even as complications or opportunistic infections associated with the disease. The present study aimed to: (I) study the linking of certain infectious viral agents with human autoimmune diseases. (II) Determine possible roles of some studied clinico-pathological factors like; gender, age and to investigate the prevalence of Seropositivity of the antibodies titer of EBV, Rubella virus and CMV with autoimmune diseases development in human. In this study, four groups candidates of Celiac diseases (CD) n=31, Diabetes Mellitus –I (DM-I) n=30, Rheumatoid Arthritis (RA) n=30 & Systemic lupus erythematous (SLE) n=30 were studied from 1st – 30th of January 2017 at Medical City \ Baghdad. Demographic and laboratory data were collected. All the samples were examined for the presence of EBV VCA-IgG, Rubella IgG and CMV IgM by Indirect and Sandwich ELISA techniques by using a commercial kits from DIAGNOSTIC AUTOMATIONS CO. \ USA. A total of 121 autoimmune disease patients were studied , the overall positive results for EBV VCA IgG was (68.6 %) while for Rubella IgG was (50.4%) and for CMV IgG was (52.1%) with significant differences in comparing with the negative results (p < 0.05). Celiac disease and diabetic type-I patients had been detected with high Seropositivity for EBV VCA IgG as (22.3%) for each of them, While the high positive results of Rubella IgG was detected in Celiac disease patients as (16.5%). Finally, the diabetic Type-I patients showed the most high Seropositivity for CMV IgG as (17.4%) in significant differences with the negative results regarding to all the other positive ones (p < 0.05).

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108

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